Sandra kaufmann exlibris6/13/2023 ![]() If it had no affect on that category, then a given agent got a 0 score. When we look at a given compound, we ask is it an epigenetic modifier, does it affect your genes, does it affect your mitochondria, etc. Kaufmann has a rating system for judging potential anti-aging compounds based on which ones affect which of the 7 tenets of aging, so each agent got a 7 digit rating. On average, we lose between 47 and 67 base pairs per year.ġ4:47 Dr. Kaufmann does think that the Telomere length test is one way to assess the level of our biological aging, though results may vary depending upon which company runs the test. Russell Jaffe went through which predictive biomarkers he recommends to assess a person’s aging level in episode 100, Predictive Biomarkers with Dr. On a previous episode of Rational Wellness, Dr. Bill Andrews to sort through 400 different lab markers to figure out which ones are the most important to analyze where a person’s biological aging level is, to help target an anti-aging program. Kaufmann is involved with a project with Dr. We need a more comprehensive program.ġ0:50 Dr. Kaufmann points out that if you don’t address all 7 categories of aging, you will fail. Some anti-aging experts are obsessed with fasting and AMP kinase or with mTOR or with stem cells. And you may get an accumulation of lipofuscin over time. ![]() ![]() Tenet seven is waste management, because glucose is an issue. Tenet five is security, which is your immune system, which can go waywire as you age. Tenet four is what she calls Quality Control, which refers to DNA and protein repair mechanisms, which also includes autophagy, which is the recycling of organelles. There is also the mTOR pathway that controls catabolism and metabolism, the breakdown and the building of tissues. There are also 7 mammalian sirtuin systems. And you can take agents that fool your body into telling you that you’re starving. These tell your body that you are starving and it puts yourself in a state of hibernation. Tenet three has to do with various pathways related to aging, including the AMP kinase pathway, which is activated by caloric restriction and fasting. Important factors here include free radicals and nicotinamide deficiency. Tenet two is your mitochondria and energy production. Also, epigenetic modifications of your DNA tend to occur with aging. Tenet one is DNA alterations. The ends of your chromosomes, referred to as telomeres tend to get shorter as you age and this is a major problem. Kaufmann took the analysis of the aging process down to the cellular level. Kaufmann, in her book The Kaufmann Protocol, Why We Age, and How to Stop It, breaks down the concept of aging into 7 different physiological pathways or tenets of why we age. Sandra Kaufmann discusses Anti-aging strategies with Dr. Podcast: Play in new window | Download | Embedĭr.
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